Remission induction with cytosine arabinoside and L-asparaginase in acute lymphoblastic leukaemia.

نویسندگان

  • T J McElwain
  • R M Hardisty
چکیده

Nine patients with acute lymphoblastic leukaemia in relapse were treated with a course of cytosine arabinoside followed immediately by a course of L-asparaginase. Eight patients achieved complete remission of their disease. This combination of drugs is sufficiently effective to suggest that further trial is needed. It is possible that the combination has a synergistic effect.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Multicentre pilot study for therapy of acute lymphoblastic and acute undifferentiated leukemia in adults.

In 1978 a study group was formed in the Federal Republic of Germany for the treatment of acute lymphoblastic leukemia (ALL) und acute undifferentiated leukemia (AUL) in adults. A modified form of an intensive induction and consolidation regimen successful in children with ALL [I] was used. The objective was to determine whether a prolonged remission induction and the addition of the drugs cyclo...

متن کامل

Treatment of adult lymphoblastic leukaemia using cyclical chemotherapy with three combinations of four drugs (COAP, POMP, TRAP schedule).

Seventeen adult patients with previously untreated acute lymphoblastic leukaemia (ALL) were entered into a schedule of chemotherapy in which 3 combinations, each of 4 drugs, were administered in a predetermined cyclical rotation in combination with cranial irradiation and intrathecal injections of methotrexate. Of the 17 patients, 16 completed induction therapy and 15 (94%) entered remission. T...

متن کامل

The feasibility of opal/high dose Ara-C treatment of adult acute lymphoblastic leukaemia.

Studies conducted at St. Bartholomew's Hospital between 1972 and 1982 into the treatment of acute lymphoblastic leukaemia (ALL) in adults showed a complete remission (CR) rate of 65% (73/112) using a combination of vincristine, prednisolone, adriamycin, and L-asparaginase, with. CR frequency being highest in young patIents and lowest in those with L3 morphology. The duration of remission correl...

متن کامل

Myelosuppressive effect of colaspase (L-asparaginase) in initial treatment of acute lymphoblastic leukaemia.

Analysis of the remission induction phase in three Medical Research Council trials of treatment of acute lymphoblastic leukaemia has provided evidence of the adverse effect of the combination of colaspase (L-asparaginase) with vincristine and prednisolone. Significant myelosuppression, particularly of the granulocytic series, resulted in an increase in Gram-negative sepsis and death during the ...

متن کامل

of platelet aggregation . Fibrinogen mediated activation

diagnosed by morphological, cytochemical, immunological, and ultrastructural methods.' Following remission induction with daunorubicin, vincristine, prednisolone, and L-asparaginase she received maintenance treatment with methotrexate, 6 mercaptopurine, cytosine arabinoside, vincristine, and prednisolone for 12 months before this was stopped due to neutropenia. She remained well until August 19...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • British medical journal

دوره 4 5683  شماره 

صفحات  -

تاریخ انتشار 1969